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The study reveals personalized care for type 2 diabetes


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A Dundee University study found that moving away from a care regimen that suits everyone can change care for people with type 2 diabetes.

Experts from the University School of Medicine in collaboration with the University of Exeter have created a way to determine how people with type 2 diabetes differ from each other and how clinical differences between them affect their long-term risks and response to treatment.

The study analyzed data from more than 23,000 people with type 2 diabetes, using them to develop a new way to visualize how people with type 2 diabetes differ from each other based on nine clinical characteristics.

The study, conducted with the Madras Diabetes Research Foundation, was published today in Natural medicine.

“Clinically, we need to move away from a single approach to treating people with type 2 diabetes and be more precise in their care,” said Ewan Pearson, a professor of diabetic medicine at Dundee.

“Our research demonstrates how we can look at a person with type 2 diabetes and intuitively illustrate the root causes of their diabetes, and use this to better manage them to reduce individual risks.

“Imagine three women diagnosed with type 2 diabetes at age 60. One may have only mild overweight and diabetes due to reduced pancreatic insulin production. She will have slower progression of diabetes and less risk of complications.”

“Second, perhaps especially high blood pressure and be more prone to visual complications.

“The third can be very overweight with high blood fats and be more resistant to insulin, which means it will be at increased risk of heart disease. They all have type 2 diabetes, but for very different reasons and with very different profiles. , which means that different treatments can lead to better results, depending on the circumstances ”.

More than 4 million people in the UK have type 2 diabetes with complications arising from the disease, including life-threatening heart disease and kidney diseasewhile it is also the biggest cause of blindness and amputation in the UK

Anand Nair, a leading analyst at Dundee’s study, said: “Type 2 diabetes is a complex disease caused by many different mechanisms.”

“Some people develop type 2 diabetes due to different mechanisms than others, and so they can differ dramatically in their clinical characteristics, e.g. body weight, blood fat, blood pressure or their genes. This new approach helps to greatly simplify this complexity for both clinicians and patients. ”

John Dennis of the University of Exeter School of Medicine, who supported the study, said: “Clinicians are currently in a difficult position to make decisions that affect health in type 2 diabetes, based on very little evidence. Our findings use advanced data science , applied to UK health data, can provide more personalized information to support clinical care for people with type 2 diabetes. “

The study is called “Heterogeneity in phenotype, disease progression and drug response in type 2 diabetes».

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Additional information:
Anand Thakarakkattil Narayanan Nair et al., Heterogeneity in phenotype, disease progression and drug response to type 2 diabetes, Natural medicine (2022). DOI: 10.1038 / s41591-022-01790-7

Citation: Study opens personalized care for type 2 diabetes (2022, May 10), received May 10, 2022 from https://medicalxpress.com/news/2022-05-personalized-diabetes.html

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